Retatrutide vs Semaglutide
Retatrutide and Semaglutide are compared here on the things that actually differ between them: what class each belongs to, what each acts on, how each is supplied and what each costs per milligram. Where the registry has no figure for one of them the row is left out rather than filled in.
Side by side
| Retatrutide | Semaglutide | |
|---|---|---|
| Class | Triple GIP/GLP-1/glucagon receptor agonist | GLP-1 receptor agonist |
| Acts on | A single peptide with agonist activity at three receptors: GIP, GLP-1 and glucagon. The glucagon component is what distinguishes it from dual agonists such as tirzepatide. | A GLP-1 analogue modified for albumin binding and resistance to DPP-4 degradation, giving a long circulating half-life relative to native GLP-1. |
| Supplied as | Lyophilised vial, or pre-filled pen graduated in dial units. | Lyophilised vial or pre-filled pen. |
| Half-life | Long, supporting weekly intervals in clinical study design. | Approximately seven days, supporting weekly intervals. |
| Storage | Refrigerated. Pens must not be frozen. Protect from light. | Refrigerated. Do not freeze. |
| Listings | 4 | 3 |
| Price from | £160 | £60 |
What actually differs
The clearest difference is class: Retatrutide is a triple GIP/GLP-1/glucagon receptor agonist, Semaglutide is a GLP-1 receptor agonist. They are not supplied the same way. Retatrutide comes as a lyophilised vial, or pre-filled pen graduated in dial units, Semaglutide as a lyophilised vial or pre-filled pen. Half-life differs as well: Long, supporting weekly intervals in clinical study design for Retatrutide against Approximately seven days, supporting weekly intervals for Semaglutide.
Quanta Pharma Retatrutide 30mg + Free BWin stock£160- SerenQ Retatrutide Penin stock£210
VLS Retatrutide Penin stock£220
Quanta Pharma Retatrutide 50mg + Free BWin stock£225
Quanta GLP-1 5mgin stock£60- SerenQ GLP-1 10mg Penin stock£95
VLS GLP-1 5mg Penin stock£95
Availability checked 2026-09-09. The product page carries live stock.